Targeting the pathway of GSK-3β/nerve growth factor to attenuate post-infarction arrhythmias by preconditioned adipose-derived stem cells (2017)
BP 預處理的脂肪幹細胞 (BP-preconditioned ADSCs) 可以顯著降低心肌梗塞後的心律不整，並通過 PI3K/Akt/GSK-3β 路徑提升幹細胞的心臟保護效果。BP-preconditioned ADSCs 在心臟移植後對於心臟功能和心臟纖維化改善結果優於未預處理的 ADSCs 。
Lee, T. M., Harn, H. J., Chiou, T. W., Chuang, M. H., Chen, C. H., Lin, P. C., & Lin, S. Z. (2017). Targeting the pathway of GSK-3β/nerve growth factor to attenuate post-infarction arrhythmias by preconditioned adipose-derived stem cells. Journal of molecular and cellular cardiology, 104, 17–30.
Host pre-conditioning improves human adipose–derived stem cell transplantation in ageing rats after myocardial infarction: Role of NLRP3 inflammasome (2020)
BP 預處理的脂肪間質幹細胞 (BP-preconditioned ADSCs) 能顯著減少老年大鼠心臟中的 ROS level 和 NLRP3 炎症小體活性，提升脂肪幹細胞 (hADSCs) 的植入效果，以及減少心臟纖維化。BP-preconditioned ADSCs 相比未處理組，心臟纖維化降低達 40%，顯示出其在心肌梗塞後改善幹細胞植入的治療潛力。
Lee T-M, Harn H-J, Chiou T-W, et al. Host pre-conditioning improves human adipose–derived stem cell transplantation in ageing rats after myocardial infarction: Role of NLRP3 inflammasome. J Cell Mol Med. 2020; 24: 12272–12284.
Preconditioned adipose-derived stem cells ameliorate cardiac fibrosis by regulating macrophage polarization in infarcted rat hearts through the PI3K/STAT3 pathway (2019)
BP 預處理的脂肪幹細胞 (BP-preconditioned ADSCs) 能有效調節巨噬細胞表型，通過 PI3K/STAT3 路徑減少心肌纖維化，顯著提高心臟功能與幹細胞植入效果。與普通 ADSCs 相比，BP-preconditioned ADSCs 能顯著提升 M2 型巨噬細胞 (免疫調控) 浸潤和心肌 IL-10 (抗發炎) 的表現量。
Lee, TM., Harn, HJ., Chiou, TW. et al. Preconditioned adipose-derived stem cells ameliorate cardiac fibrosis by regulating macrophage polarization in infarcted rat hearts through the PI3K/STAT3 pathway. Lab Invest 99, 634–647 (2019).