Targeting the pathway of GSK-3β/nerve growth factor to attenuate post-infarction arrhythmias by preconditioned adipose-derived stem cells
BP 預處理的脂肪幹細胞 (ADSCs) 可以顯著降低心肌梗塞後的心律不整，並通過 PI3K/Akt/GSK-3β 路徑提升幹細胞的心臟保護效果。BP 預處理的 ADSCs 在心臟移植後的纖維化減少和心臟功能改善方面顯示出優於未預處理的 ADSCs 的顯著效果。
Lee, T. M., Harn, H. J., Chiou, T. W., Chuang, M. H., Chen, C. H., Lin, P. C., & Lin, S. Z. (2017). Targeting the pathway of GSK-3β/nerve growth factor to attenuate post-infarction arrhythmias by preconditioned adipose-derived stem cells. Journal of molecular and cellular cardiology, 104, 17–30.
Preconditioned adipose-derived stem cells ameliorate cardiac fibrosis by regulating macrophage polarization in infarcted rat hearts through the PI3K/STAT3 pathway
BP 預處理的脂肪幹細胞 (ADSCs) 能有效調節巨噬細胞表型，通過 PI3K/STAT3 路徑減少心肌纖維化，顯著提高心臟功能與幹細胞植入效果。與普通 ADSCs 相比，BP 預處理的 ADSCs 能顯著提升 M2 型巨噬細胞浸潤和心肌 IL-10 水平。
Lee, TM., Harn, HJ., Chiou, TW. et al. Preconditioned adipose-derived stem cells ameliorate cardiac fibrosis by regulating macrophage polarization in infarcted rat hearts through the PI3K/STAT3 pathway. Lab Invest 99, 634–647 (2019).
Remote transplantation of human adipose-derived stem cells induces regression of cardiac hypertrophy by regulating the macrophage polarization in spontaneously hypertensive rats
BP預處理的脂肪幹細胞 (hADSCs) 能顯著減少心室肥大，降低心肌中的活性氧 (ROS) 水平達 30%，並提高 M2 型巨噬細胞浸潤。這種處理方法在高血壓大鼠模型中，顯著提升了 hADSCs 的植入效率和抗纖維化效果，提供了逆轉心室肥大的新策略。
Lee, T. M., Harn, H. J., Chiou, T. W., Chuang, M. H., Chen, C. H., Chuang, C. H., Lin, P. C., & Lin, S. Z. (2019). Remote transplantation of human adipose-derived stem cells induces regression of cardiac hypertrophy by regulating the macrophage polarization in spontaneously hypertensive rats. Redox biology, 27, 101170.
Host pre-conditioning improves human adipose–derived stem cell transplantation in ageing rats after myocardial infarction: Role of NLRP3 inflammasome
BP 預處理能顯著減少老年大鼠心臟中的 ROS 水平和 NLRP3 炎症小體活性，改善了脂肪幹細胞 (hADSCs) 的植入效果，並減少心臟纖維化。BP 預處理的老年大鼠相比未處理組，心臟纖維化降低40%，顯示出在心肌梗死後改善幹細胞植入的潛力。
Lee T-M, Harn H-J, Chiou T-W, et al. Host pre-conditioning improves human adipose–derived stem cell transplantation in ageing rats after myocardial infarction: Role of NLRP3 inflammasome. J Cell Mol Med. 2020; 24: 12272–12284.