Intracerebral transplantation of autologous adipose‐derived stem cells for chronic ischemic stroke: A phase I study (2021)
思益優 (GXNPC1®) 在慢性中風患者中展現了顯著的神經功能改善：美國國家衛生院腦中風量表（NIHSS）改善了5至15分，巴氏量表提高了 25 至 50 分，且核磁共振（MRI）結果顯示患者腦梗塞區域縮小。6 個月追蹤期間無與藥物相關嚴重不良反應（SAE），驗證其臨床的安全性和效果。
Chiu, T. L., Baskaran, R., Tsai, S. T., Huang, C. Y., Chuang, M. H., Syu, W. S., Harn, H. J., Lin, Y. C., Chen, C. H., Huang, P. C., Wang, Y. F., Chuang, C. H., Lin, P. C., & Lin, S. Z. (2022). Intracerebral transplantation of autologous adipose-derived stem cells for chronic ischemic stroke: A phase I study. Journal of tissue engineering and regenerative medicine, 16(1), 3–13.
Therapeutic Effect of Ligustilide-Stimulated Adipose-Derived Stem Cells in a Mouse Thromboembolic Stroke Model (2016)
Ligustilide 處理過的脂肪間質幹細胞 (Pretreated ADSCs) 在小鼠中風模型中，相比未處理的ADSCs 顯著改善行為分數，研究結果顯示 Ligustilide pretreated ADSCs 可顯著提高幹細胞在應用於腦中風的潛力。
Chi, K., Fu, R. H., Huang, Y. C., Chen, S. Y., Lin, S. Z., Huang, P. C., Lin, P. C., Chang, F. K., & Liu, S. P. (2016). Therapeutic Effect of Ligustilide-Stimulated Adipose-Derived Stem Cells in a Mouse Thromboembolic Stroke Model. Cell transplantation, 25(5), 899–912.
The Use of ADSCs as a Treatment for Chronic Stroke (2014)
脂肪間質幹細胞 (ADSCs) 已被應用在許多中風動物疾病模型，植入後顯示安全性高，且這些幹細胞治療在減少中風後的神經損傷和改善神經功效，顯示其臨床應用的潛力。
Chan, T. M., Harn, H. J., Lin, H. P., Chiu, S. C., Lin, P. C., Wang, H. I., Ho, L. I., Chuu, C. P., Chiou, T. W., Hsieh, A. C., Chen, Y. W., Ho, W. Y., & Lin, S. Z. (2014). The use of ADSCs as a treatment for chronic stroke. Cell transplantation, 23(4-5), 541–547.